![]() ![]() Warburg attributed this phenomenon to mitochondrial dysfunction in tumor cells and suggested that destruction of the mitochondrial respiratory chain caused tumor cells to rely on glycolysis. ![]() This effect is based on the fact that tumor cells use glycolysis rather than the tricarboxylic acid (TCA) cycle for energy production. The first description of the function of mitochondria in tumorigenesis used the term ‘aerobic glycolysis’, which is now known as the Warburg effect. Mitochondria, as energy centers, play an important role in cancer metabolism. The mitochondria modulate cell metabolism, reactive oxygen species (ROS) genesis, cell apoptosis, and the universal second messenger, calcium. The mitochondrion is a double membrane-bound half-independent organelle that shoulders most of the metabolic activities in the cell. ![]()
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